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One Strike and You’re Out: CTCF is a Haploinsufficient Tumor Suppressor

Brennan, Greg (2014) One Strike and You’re Out: CTCF is a Haploinsufficient Tumor Suppressor. Science Spotlight, 4 (6).

One Strike and You’re Out- CTCF is a Haploinsufficient Tumor Suppressor.pdf - Published Version
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Additional Information: Kemp CJ, Moore JM, Moser R, Bernard B, Teater M, Smith LE, Rabaia NA, Gurley KE, Guinney J, Busch SE, Shaknovich R, Lobanenkov VV, Liggitt D, Shmulevich I, Melnick A, Filippova GN. 2014. CTCF Haploinsufficiency Destabilizes DNA Methylation and Predisposes to Cancer. Cell Rep. 1020-9. doi: 10.1016/j.celrep.2014.04.004. See also: Filippova GN, Lindblom A, Meincke LJ, Klenova EM, Neiman PE, Collins SJ, Doggett NA, Lobanenkov VV. 1998. A widely expressed transcription factor with multiple DNA sequence specificity, CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers. Genes Chromosomes Cancer. 22(1):26-36. Filippova GN. 2008. Genetics and epigenetics of the multifunctional protein CTCF. Curr Top Dev Biol. 80:337-60 Moore JM, Rabaia NA, Smith LE, Fagerlie S, Gurley K, Loukinov D, Disteche CM, Collins SJ, Kemp CJ, Lobanenkov VV, Filippova GN. 2012. Loss of maternal CTCF is associated with peri-implantation lethality of Ctcf null embryos. PLoS One. 7(4):e34915. doi: 10.1371/journal.pone.0034915.
Collections: Science Spotlight
Depositing User: Ben Abraham
Date Deposited: 19 Mar 2015 18:49
Last Modified: 19 Mar 2015 18:49

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