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Molecular cytogenetic evidence of rearrangements on the Y chromosome of the threespine stickleback fish.

Ross, Joseph A and Peichel, Catherine L (2008) Molecular cytogenetic evidence of rearrangements on the Y chromosome of the threespine stickleback fish. Genetics, 179 (4). pp. 2173-2182. ISSN 0016-6731

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To identify the processes shaping vertebrate sex chromosomes during the early stages of their evolution, it is necessary to study systems in which genetic sex determination was recently acquired. Previous cytogenetic studies suggested that threespine stickleback fish (Gasterosteus aculeatus) do not have a heteromorphic sex chromosome pair, although recent genetic studies found evidence of an XY genetic sex-determination system. Using fluorescence in situ hybridization (FISH), we report that the threespine stickleback Y chromosome is heteromorphic and has suffered both inversions and deletion. Using the FISH data, we reconstruct the rearrangements that have led to the current physical state of the threespine stickleback Y chromosome. These data demonstrate that the threespine Y is more degenerate than previously thought, suggesting that the process of sex chromosome evolution can occur rapidly following acquisition of a sex-determining region.

Item Type: Article
Additional Information: Available in PMC on 11/01/08.
DOI: 10.1534/genetics.108.088559
PubMed ID: 18689886
PMCID: PMC2516089
Keywords or MeSH Headings: Animals Chromosome Deletion* Chromosome Inversion* Chromosome Mapping Chromosomes, Artificial, Bacterial Evolution, Molecular Female In Situ Hybridization, Fluorescence Karyotyping Male Sex Determination Processes Smegmamorpha/genetics* Y Chromosome*
Subjects: Cellular and Organismal Processes > Evolution
Organisms > Model organisms
Cellular and Organismal Processes > Genetic processes > DNA rearrangement
Depositing User: Library Staff
Date Deposited: 29 Sep 2008 23:03
Last Modified: 12 Oct 2011 20:41

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