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A mouse model repository for cancer biomarker discovery.

Kelly-Spratt, Karen S and Kasarda, A Erik and Igra, Mark and Kemp, Christopher J (2008) A mouse model repository for cancer biomarker discovery. Journal of Proteome Research, 7 (8). pp. 3613-3618. ISSN 1535-3893

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Early detection of cancer using biomarkers obtained from blood or other easily accessible tissues would have a significant impact on reducing cancer mortality. However, identifying new blood-based biomarkers has been hindered by the dynamic complexity of the human plasma proteome, confounded by genetic and environmental variability, and the scarcity of high quality controlled samples. In this report, we discuss a new paradigm for biomarker discovery through the use of mouse models. Inbred mouse models of cancer recapitulate many critical features of human cancer, while eliminating sources of environmental and genetic variability. The ability to collect samples from highly matched cases and controls under identical conditions further reduces variability which is critical for successful biomarker discovery. We describe the establishment of a repository containing tumor, plasma, urine, and other tissues from 10 different mouse models of human cancer, including two breast, two lung, two prostate, two gastrointestinal, one ovarian, and one skin tumor model. We present the overall design of this resource and its potential use by the research community for biomarker discovery.

Item Type: Article or Abstract
DOI: 10.1021/pr800210b
PubMed ID: 18624399
Grant Numbers: 23XS144A, 27XS102
Keywords or MeSH Headings: Animals; Biological Specimen Banks; Disease Models, Animal; Female; Male; Mice; Mice, Mutant Strains; National Cancer Institute (U.S.); Neoplasms, Experimental/blood/diagnosis/urine; Proteome/analysis; Tumor Markers, Biological/analysis/blood/urine; United States;
Subjects: Research Methodologies > Genomics > Molecular Markers
Diseases > Solid tumors
Organisms > Model organisms
Depositing User: Library Staff
Date Deposited: 03 Oct 2008 18:53
Last Modified: 14 Feb 2012 14:42

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