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TGF-beta has paradoxical and context dependent effects on proliferation and anoikis in human colorectal cancer cell lines.

Muñoz, Nina M and Baek, Ji Yeon and Grady, William M (2008) TGF-beta has paradoxical and context dependent effects on proliferation and anoikis in human colorectal cancer cell lines. Growth factors (Chur, Switzerland), 26 (5). pp. 254-262. ISSN 1029-2292

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Abstract

Transforming growth factor-beta (TGF-beta) is a pluripotent cytokine that can have both tumor suppressing and tumor promoting effects on epithelial cells. It is unclear what determines when TGF-beta and its signaling pathway act predominantly as a tumor suppressor pathway or as a tumor-promoter pathway and whether TGF-beta can have both classes of effects concurrently on a cell. We investigated the effect of TGF-beta on anoikis in colorectal cancer cell lines sensitive to TGF-beta-mediated growth inhibition to determine if the context of the cells could be one of the factors that would affect whether TGF-beta exerts tumor suppressor or oncogene activity on colon cancer cells. We observed variable effects of TGF-beta on anoikis in these cell lines, even though they all are growth-inhibited by TGF-beta. Thus, we show that TGF-beta has variable effects on anoikis in colon cancer cell lines that likely reflects the effects of concurrent gene mutations in the cancer cells and the activation state of the signaling pathways controlled by these genes.

Item Type: Article
Additional Information: This is an electronic version of an article published in Growth Factors, Volume 26, Issue 5 October 2008 , pages 254 - 262. Growth Factors is available online at informaworldTM with the open URL of your article.
DOI: 10.1080/08977190802291667
PubMed ID: 18651288
NIHMSID: NIHMS78741
PMCID: PMC2694855
Grant Numbers: 5R01CA115513-03
Keywords or MeSH Headings: Anoikis/*drug effects/*genetics; Cell Line, Tumor; Cell Proliferation/*drug effects; Colorectal Neoplasms/*genetics; Culture Media, Serum-Free; Genes, Reporter; HCT116 Cells; Humans; Luciferases/metabolism; Transforming Growth Factor beta/genetics/metabolism/*pharmacology
Subjects: Molecules > Cytokines
Diseases > Solid tumors > Digestive system cancer
Cellular and Organismal Processes > Cell Physiology > Cell proliferation
Cellular and Organismal Processes > Cell Physiology > Cell death
Depositing User: Library Staff
Date Deposited: 12 Nov 2008 23:51
Last Modified: 14 Feb 2012 14:42
URI: http://authors.fhcrc.org/id/eprint/93

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