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Translocated c-myc genes produce chimeric transcripts containing antisense sequences of the immunoglobulin heavy chain locus in mouse plasmacytomas.

Julius, M A and Street, A J and Fahrlander, P D and Yang, J Q and Eisenman, R N and Marcu, K B (1988) Translocated c-myc genes produce chimeric transcripts containing antisense sequences of the immunoglobulin heavy chain locus in mouse plasmacytomas. Oncogene, 2 (5). pp. 469-476. ISSN 0950-9232

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Abstract

Immunoglobulin heavy chain gene antisense transcripts contribute to the expression of translocated c-myc genes in several murine plasma cell tumors. These novel, chimeric transcripts comprise 5-50% of steady-state c-myc mRNA. Two transcripts isolated as cDNA clones use the normal splice donor and acceptor sites within the c-myc first intron. Another cDNA clone has the potential for encoding two types of c-myc proteins. The significance of immunoglobulin heavy chain gene antisense transcripts and transcriptional competence of the immunoglobulin heavy chain locus for c-myc expression is discussed.

Item Type: Article
Additional Information: This article is not currently available online.
PubMed ID: 2453828
Grant Numbers: GM26939, CA36246, CA20525, CA28151, CA09176
Keywords or MeSH Headings: Animals; Base Sequence; Gene Expression Regulation; Genes, Immunoglobulin; Genes, Switch; Immunoglobulin Heavy Chains/genetics; Immunoglobulin gamma-Chains/genetics; Mice; Molecular Sequence Data; Plasmacytoma/genetics; Proto-Oncogene Proteins/genetics; RNA/genetics; RNA, Antisense; RNA, Messenger/genetics; RNA, Neoplasm/genetics; Transcription, Genetic; Translocation, Genetic;
Subjects: Molecules > Proteins
Molecules > Genes > Oncogenes
Cellular and Organismal Processes > Genetic processes > Transcription
Depositing User: Library Staff
Date Deposited: 04 Dec 2008 20:53
Last Modified: 21 May 2010 22:35
URI: http://authors.fhcrc.org/id/eprint/121

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