Julius, M A and Street, A J and Fahrlander, P D and Yang, J Q and Eisenman, R N and Marcu, K B (1988) Translocated c-myc genes produce chimeric transcripts containing antisense sequences of the immunoglobulin heavy chain locus in mouse plasmacytomas. Oncogene, 2 (5). pp. 469-476. ISSN 0950-9232
Abstract
Immunoglobulin heavy chain gene antisense transcripts contribute to the expression of translocated c-myc genes in several murine plasma cell tumors. These novel, chimeric transcripts comprise 5-50% of steady-state c-myc mRNA. Two transcripts isolated as cDNA clones use the normal splice donor and acceptor sites within the c-myc first intron. Another cDNA clone has the potential for encoding two types of c-myc proteins. The significance of immunoglobulin heavy chain gene antisense transcripts and transcriptional competence of the immunoglobulin heavy chain locus for c-myc expression is discussed.
| Item Type: | Article or Abstract |
|---|---|
| Additional Information: | This article is not currently available online. |
| PubMed ID: | 2453828 |
| Grant Numbers: | GM26939, CA36246, CA20525, CA28151, CA09176 |
| Keywords or MeSH Headings: | Animals; Base Sequence; Gene Expression Regulation; Genes, Immunoglobulin; Genes, Switch; Immunoglobulin Heavy Chains/genetics; Immunoglobulin gamma-Chains/genetics; Mice; Molecular Sequence Data; Plasmacytoma/genetics; Proto-Oncogene Proteins/genetics; RNA/genetics; RNA, Antisense; RNA, Messenger/genetics; RNA, Neoplasm/genetics; Transcription, Genetic; Translocation, Genetic; |
| Subjects: | Molecules > Proteins Molecules > Genes > Oncogenes Cellular and Organismal Processes > Genetic processes > Transcription |
| Depositing User: | Library Staff |
| Date Deposited: | 04 Dec 2008 20:53 |
| Last Modified: | 21 May 2010 22:35 |
| URI: | http://authors.fhcrc.org/id/eprint/121 |
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