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Metastasis suppressor function of tumor necrosis factor-related apoptosis-inducing ligand-R in mice: implications for TRAIL-based therapy in humans?

Grosse-Wilde, Anne and Kemp, Christopher J (2008) Metastasis suppressor function of tumor necrosis factor-related apoptosis-inducing ligand-R in mice: implications for TRAIL-based therapy in humans? Cancer research, 68 (15). pp. 6035-6037. ISSN 1538-7445

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Article URL: http://cancerres.aacrjournals.org/cgi/reprint/68/1...

Abstract

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising candidate for cancer therapy, as it can induce apoptosis specifically in tumor cells but not in normal cells. Although earlier mouse tumor studies revealed a strong tissue dependency of TRAIL and its death receptor in suppressing primary tumorigenesis or experimental metastases, we recently found that TRAIL-R inhibits lymph node metastases without affecting primary tumor formation in a mouse model of multistage skin tumorigenesis. This finding uncouples the role of TRAIL in primary tumorigenesis from metastasis formation, likely by sensitization of previously TRAIL-resistant tumor cells upon detachment, an early step required for metastasis formation. Therefore, TRAIL-R is a novel metastasis suppressor, suggesting that TRAIL-related tumor therapy might be most effective in primary tumors and early metastatic cancers, before selection for TRAIL resistance occurs.

Item Type: Article
Additional Information: This article is available to subscribers only via the URL above for the first 12 months after publication.
DOI: 10.1158/0008-5472.CAN-08-0078;
PubMed ID: 18676822
NIHMSID: NIHMS96062
PMCID: PMC2665198
Grant Numbers: R01 CA070414-10, R01 CA099517-05
Keywords or MeSH Headings: Animals; Antineoplastic Agents/pharmacology/therapeutic use; Humans; Mice; Neoplasm Metastasis/prevention & control; TNF-Related Apoptosis-Inducing Ligand/physiology;
Subjects: Therapeutics > Biological Therapy > Immunotherapy
Diseases > Solid tumors
Cellular and Organismal Processes > Cell Physiology > Cell death
Depositing User: Library Staff
Date Deposited: 18 Feb 2009 19:55
Last Modified: 14 Feb 2012 14:42
URI: http://authors.fhcrc.org/id/eprint/251

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