Grosse-Wilde, Anne and Kemp, Christopher J (2008) Metastasis suppressor function of tumor necrosis factor-related apoptosis-inducing ligand-R in mice: implications for TRAIL-based therapy in humans? Cancer research, 68 (15). pp. 6035-6037. ISSN 1538-7445
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Abstract
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising candidate for cancer therapy, as it can induce apoptosis specifically in tumor cells but not in normal cells. Although earlier mouse tumor studies revealed a strong tissue dependency of TRAIL and its death receptor in suppressing primary tumorigenesis or experimental metastases, we recently found that TRAIL-R inhibits lymph node metastases without affecting primary tumor formation in a mouse model of multistage skin tumorigenesis. This finding uncouples the role of TRAIL in primary tumorigenesis from metastasis formation, likely by sensitization of previously TRAIL-resistant tumor cells upon detachment, an early step required for metastasis formation. Therefore, TRAIL-R is a novel metastasis suppressor, suggesting that TRAIL-related tumor therapy might be most effective in primary tumors and early metastatic cancers, before selection for TRAIL resistance occurs.
| Item Type: | Article or Abstract |
|---|---|
| Additional Information: | This article is available to subscribers only via the URL above for the first 12 months after publication. |
| DOI: | 10.1158/0008-5472.CAN-08-0078; |
| PubMed ID: | 18676822 |
| NIHMSID: | NIHMS96062 |
| PMCID: | PMC2665198 |
| Grant Numbers: | R01 CA070414-10, R01 CA099517-05 |
| Keywords or MeSH Headings: | Animals; Antineoplastic Agents/pharmacology/therapeutic use; Humans; Mice; Neoplasm Metastasis/prevention & control; TNF-Related Apoptosis-Inducing Ligand/physiology; |
| Subjects: | Therapeutics > Biological Therapy > Immunotherapy Diseases > Solid tumors Cellular and Organismal Processes > Cell Physiology > Cell death |
| Depositing User: | Library Staff |
| Date Deposited: | 18 Feb 2009 19:55 |
| Last Modified: | 14 Feb 2012 14:42 |
| URI: | http://authors.fhcrc.org/id/eprint/251 |
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