No reduction in C-reactive protein following a 12-month randomized controlled trial of exercise in men and women.

Campbell, Kristin L. and Campbell, Peter T. and Ulrich, Cornelia M. and Wener, Mark and Alfano, Catherine M. and Foster-Schubert, Karen and Rudolph, Rebecca E. and Potter, John D. and McTiernan, Anne (2008) No reduction in C-reactive protein following a 12-month randomized controlled trial of exercise in men and women. Cancer Epidemiology Biomarkers and Prevention, 17. pp. 1714-1718. ISSN 1538-7755

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Abstract

Low-grade systemic inflammation is suggested to play a role in the development of several chronic diseases including cancer. Higher levels of physical activity and lower adiposity have been associated with reduced levels of markers of systemic inflammation, such as C-reactive protein (CRP); however, reductions in CRP have not been observed consistently in randomized controlled trials of exercise. Purpose: To examine the effect of a 12-month aerobic exercise intervention on CRP levels in men and women. Methods: 102 men and 100 women, sedentary and aged 40-75 years, mean BMI of 29.9 and 28.7 kg/m2, respectively, were randomly assigned to a 12-month moderate-to-vigorous aerobic exercise intervention (6 d/wk, 60 min/d, 60-85% maximum heart rate) or control group. Fasting blood samples were collected at baseline and at 12-months. CRP levels were measured by high-sensitivity latex-enhanced nephelometry. Results: At baseline, CRP was 1.16 mg/L and 2.11 for men and women, respectively, and CRP was correlated with percent body fat (r=0.48, p ≤0.001), BMI (r=0.37, p ≤0.001) and aerobic fitness (r=-0.49, p ≤0.001). No intervention effects were observed for CRP in men or women, or when stratified by baseline BMI (< 30 kg/m2 vs. ≥ 30 kg/m2) , baseline CRP (< 3 mg/L vs. ≥ 3 mg/L) or change in body weight, body composition or aerobic fitness. Conclusion: A 12 month moderate-to-vigorous aerobic exercise intervention did not affect CRP levels in previously sedentary men or women with average-risk CRP values at baseline.

Item Type:	Article or Abstract
Additional Information:	This article is freely available at the journal site and in PubMed.
DOI:	10.1158/1055-9965.EPI-08-0088
PubMed ID:	18628422
NIHMSID:	NIHMS50136
PMCID:	PMC2493470
Grant Numbers:	U54 CA116847, R01 CA 77572-01
Keywords or MeSH Headings:	MH - Adult MH - Aged MH - Body Weight MH - C-Reactive Protein/*metabolism MH - Colonic Neoplasms/*blood/diagnosis/epidemiology MH - Exercise/*physiology MH - Exercise Test/*methods MH - Female MH - Follow-Up Studies MH - Humans MH - Incidence MH - Male MH - Middle Aged MH - Prognosis MH - Retrospective Studies MH - Risk Factors MH - Time Factors MH - Tumor Markers, Biological/blood MH - United States/epidemiology
Subjects:	Health Care > Risk and Preventive Health Services > Exercise Research Methodologies > Clinical Trials Health Care > Risk and Preventive Health Services
Depositing User:	Users 34 not found.
Date Deposited:	04 Aug 2008 23:30
Last Modified:	14 Feb 2012 14:42
URI:	http://authors.fhcrc.org/id/eprint/5

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