Dolle, Jessica M. and Daling, Janet R. and White, Emily and Brinton, Louise A. and Doody, David R. and Porter, Peggy L. and Malone, Kathleen E. (2009) Risk Factors for Triple-Negative Breast Cancer in Women Under Age 45. Cancer Epidemiology, Biomarkers & Prevention, 18 (4). pp. 1157-1166. ISSN 1055-9965
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Abstract
Little is known about the etiologic profile of triple-negative breast cancer (negative for estrogen receptor/progesterone receptor/human epidermal growth factor), a breast cancer subtype associated with high mortality and inadequate therapeutic options. We undertook this study to assess the risk for triple-negative breast cancer among women 45 years of age and younger in relation to demographic/lifestyle factors, reproductive history, and oral contraceptive use. Study participants were ascertained in two previous population-based, case-control studies. Eligible cases included all primary invasive breast cancers among women ages 20 to 45 years in the Seattle-Puget Sound area, diagnosed between January 1983 and December 1992, for whom complete data was obtained for estrogen receptor, progesterone receptor, and human epidermal growth factor status (n = 897; including n = 187 triple-negative breast cancer cases). Controls were age matched and ascertained via random digit dialing. Oral contraceptive use >/=1 year was associated with a 2.5-fold increased risk for triple-negative breast cancer (95% confidence interval, 1.4-4.3) and no significantly increased risk for non-triple-negative breast cancer (Pheterogeneity = 0.008). Furthermore, the risk among oral contraceptive users conferred by longer oral contraceptive duration and by more recent use was significantly greater for triple-negative breast cancer than non-triple-negative breast cancer (Pheterogeneity = 0.02 and 0.01, respectively). Among women </=40 years, the relative risk for triple-negative breast cancer associated with oral contraceptive use >/=1 year was 4.2 (95% confidence interval, 1.9-9.3), whereas there was no significantly increased risk with oral contraceptive use for non-triple-negative breast cancer among women </=40 years, nor for triple-negative breast cancer or non-triple-negative breast cancer among women 41 to 45 years of age. In conclusion, significant heterogeneity exists for the association of oral contraceptive use and breast cancer risk between triple-negative breast cancer and non-triple-negative breast cancer among young women, lending support to a distinct etiology.
| Item Type: | Article or Abstract |
|---|---|
| Additional Information: | This article is available to subscribers only via the URL above for the first 12 months post-publication. |
| DOI: | 10.1158/1055-9965.EPI-08-1005 |
| PubMed ID: | 19336554 |
| NIHMSID: | NIHMS101174 |
| PMCID: | PMC2754710 |
| Grant Numbers: | R01 CA059736-10, N01 CP95671, R01 CA41416, R01 CA098858-03, N01 PC35142 |
| Keywords or MeSH Headings: | * Adult * Breast Neoplasms/chemically induced* * Breast Neoplasms/epidemiology * Breast Neoplasms/metabolism * Case-Control Studies * Contraceptives, Oral, Hormonal/adverse effects* * Female * Humans * Middle Aged * Neoplasm Invasiveness * Receptor, erbB-2/metabolism * Receptors, Estrogen/metabolism * Receptors, Progesterone/metabolism * Risk Factors * Young Adult |
| Subjects: | Diseases > Solid tumors > Breast cancer Research Methodologies > Epidemiology > Risk assessment |
| Depositing User: | Library Staff |
| Date Deposited: | 29 Jan 2009 19:41 |
| Last Modified: | 14 Feb 2012 14:42 |
| URI: | http://authors.fhcrc.org/id/eprint/236 |
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