Reding, Kerryn W. and Daling, Janet R. and Doody, David R. and O'Brien, Cecilia A. and Porter, Peggy L. and Malone, Kathleen E. (2008) The Effect of Pre-Diagnostic Alcohol Consumption on Survival after Breast Cancer in Young Women. Cancer Epidemiology Biomarkers and Prevention, 17 (8). pp. 1988-1996. ISSN 1538-7755
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Abstract
Background: Alcohol consumption has been comprehensively investigated as an etiologic risk factor for breast cancer but has received little attention in terms of its impact on prognosis after breast cancer, particularly for young women. Methods: 1286 women diagnosed with invasive breast cancer at or before 45 years of age from two population-based case-control studies in the Seattle-Puget Sound region were followed from their diagnosis of breast cancer (between January 1983 and December 1992) for survival through June 2002, during which time 364 women had died. Cox proportional hazards modeling was used to assess the effect of pre-diagnostic alcohol consumption on the risk of dying. Results: After adjusting for age and diagnosis year, compared to non-drinkers, women who consumed alcohol in the 5 years prior to diagnosis had a decreased risk of death [>0 to <3 drinks per week: HR(hazard ratio) = 0.7 (95% CI: 0.6-0.95); 3 to <7 drinks per week: RR = 0.6 (95% CI: 0.4-0.8); ≥ 7 drinks per week: RR = 0.7 (95% CI: 0.5-0.9)]. This association was unchanged upon additional adjustment for potential confounders including most notably treatment, stage at diagnosis, and mammogram history. Conclusion: These results suggest that women who consume alcohol prior to a diagnosis of breast cancer have improved survival which does not appear to be attributable to differences in stage, screening or treatment.
| Item Type: | Article or Abstract |
|---|---|
| Additional Information: | This article is freely available in PubMed Central and via the URL above. |
| DOI: | 10.1158/1055-9965.EPI-07-2897 |
| PubMed ID: | 18664549 |
| NIHMSID: | NIHMS75420 |
| PMCID: | PMC2605937 |
| Grant Numbers: | R01 CA059736-07, R01 CA059736-08, R01 CA059736-09, R01 CA059736-10, NO1 PC035142, T32 CA009168-32, 06-1-0312 |
| Keywords or MeSH Headings: | Adult; *Alcohol Drinking; Breast Neoplasms/chemically induced/*mortality/pathology; Female; Humans; Interviews as Topic; Neoplasm Invasiveness; Prognosis; Proportional Hazards Models; Risk Factors; Survival Rate |
| Subjects: | Diseases > Solid tumors > Breast cancer Psychology > Behavior |
| Depositing User: | authors@FHCRC Administrator-Import |
| Date Deposited: | 23 Oct 2008 17:17 |
| Last Modified: | 14 Feb 2012 14:42 |
| URI: | http://authors.fhcrc.org/id/eprint/29 |
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