Characteristics of chronic GVHD after cord blood transplantation.

Newell, L F and Flowers, M E D and Gooley, T A and Milano, F and Carpenter, P A and Martin, P J and Delaney, C (2013) Characteristics of chronic GVHD after cord blood transplantation. Bone marrow transplantation. ISSN 1476-5365 (In Press)

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Abstract

Most reports of chronic GVHD after cord blood transplantation (CBT) have utilized traditional diagnostic criteria. We used traditional criteria and National Institutes of Health (NIH) criteria prospectively to evaluate chronic GVHD in a cohort of 87 adult and pediatric recipients of single or double unrelated CBT for treatment of hematologic malignancies. Fifty-four patients developed traditionally defined chronic GVHD, for an estimated 2-year probability of 64%. Among 54 patients, 25 (46%) met the NIH criteria for persistent, recurrent or late acute GVHD at onset. Twenty-four (44%) had overlap chronic GVHD, including one who presented initially with late acute GVHD, and only seven (13%) had classic chronic GVHD, including one who also presented initially with late acute GVHD. Among patients who successfully discontinued all systemic immunosuppression (SI), the median time to discontinuation of corticosteroid treatment was 315 days (range 28-977), and the median time to discontinuation of all SI was 353 days (range 67-977). Chronic GVHD diagnosed by traditional criteria after CBT had a predominance of acute GVHD clinical features.Bone Marrow Transplantation advance online publication, 15 April 2013; doi:10.1038/bmt.2013.48.

Item Type:	Article or Abstract
DOI:	10.1038/bmt.2013.48
PubMed ID:	23584444
NIHMSID:	NIHMS472670
Grant Numbers:	T32 HL007093, K23 HL077446 , R24 HL074445 , P01 CA018029
Subjects:	Diseases > Graft vs Host
Fred Hutch Divisions:	Clinical Research
Depositing User:	Library Staff
Date Deposited:	25 Apr 2013 17:22
Last Modified:	25 Apr 2013 17:22
URI:	http://authors.fhcrc.org/id/eprint/605

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