Setting the stage: host invasion by HIV.

Hladik, Florian and McElrath, M Juliana (2008) Setting the stage: host invasion by HIV. Nature reviews. Immunology, 8 (6). pp. 447-457. ISSN 1474-1741

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Abstract

For more than two decades, HIV has infected millions of people worldwide each year through mucosal transmission. Our knowledge of how HIV secures a foothold at both the molecular and cellular levels has been expanded by recent investigations that have applied new technologies and used improved techniques to isolate ex vivo human tissue and generate in vitro cellular models, as well as more relevant in vivo animal challenge systems. Here, we review the current concepts of the immediate events that follow viral exposure at genital mucosal sites where most documented transmissions occur. Furthermore, we discuss the gaps in our knowledge that are relevant to future studies, which will shape strategies for effective HIV prevention.

Item Type:	Article or Abstract
Additional Information:	This article is available to subscribers only via the URL above.
DOI:	10.1038/nri2302
PubMed ID:	18469831
NIHMSID:	NIHMS51727
PMCID:	PMC2587276
Grant Numbers:	R37 AI035605-14, K08 AI051980-05, R01 HD051455-02, R01 HD051455-02S1
Keywords or MeSH Headings:	Animals; HIV Infections/immunology/prevention & control/transmission/virology; HIV-1/immunology/pathogenicity; Humans;
Subjects:	Diseases > Viral diseases Organisms > Viruses Health Care > Risk and Preventive Health Services
Depositing User:	Library Staff
Date Deposited:	14 Aug 2008 21:22
Last Modified:	14 Feb 2012 14:42
URI:	http://authors.fhcrc.org/id/eprint/7

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